If you recall from last post, lots of sugar consumed leads to lots of triglycerides which are transported by lots of VLDL’s which deliver triglycerides and become lots of LDL’s which among other things can damage our arteries….Whew!

Today, I want to fill in some of the blanks on why our arteries, under these conditions, are set up for blockage. It goes back to sugar and insulin. Too much sugar wreaks havoc by multiple mechanisms:

1. Excess sugar combines with proteins to form advanced glycated end products (AGES) which are pro-inflammatory.
2. One of these AGES is sugar + LDL. Glycated LDL is more likely to damage arteries.
3. The sugar, fructose, is especially prone to cause fatty liver which is an inflammatory condition and ultimately impacts arteries.
4. Excess sugar leads to excess insulin which causes numerous problems:
   – high blood pressure which damages arteries
   – visceral fat stores, which are never healthy beyond very small amounts, secrete pro inflammatory cytokines.
    – insulin inhibits an enzyme which is responsible for producing anti- inflammatory prostaglandins thus raising overall inflammation
    – excess insulin leads to heart disease in women by lowering estradiol and raising testosterone
     – paradoxically excess insulin leads to heart disease in men by lowering testosterone and raising estrogen
     – insulin raises uric acid levels which causes inflammation in joints (gout) as well as systemic inflammation

As you can see, when this process leads to formation of lots of LDL particles, the table is set for these particles to enter inflamed and damaged arterial walls leading to plaques which can grow and reduce blood flow or rupture and cause sudden arterial blockage.

At the risk of being painfully repetitive, I’ll summarize this series of posts about triglycerides: Too much sugar consumption leads to high triglyceride levels. These high triglycerides are a sign of a damaged metabolism which results in obesity, chronic inflammation, diabetes, gout, fatty liver, high blood pressure  and arterial disease (heart disease, stroke and peripheral arterial disease) and much more – basically most all of the diseases of modern civilization. Bottom line: reduce sugar/starch intake and keep your triglycerides below 90.